Hidden Signs – ALS and the Motor Neuron Spectrum

This CME-accredited session explores the early presentation of amyotrophic lateral sclerosis (ALS) and motor neuron spectrum disorders, which often begin with subtle, focal, or atypical symptoms that may be mistaken for common musculoskeletal, peripheral nerve, or benign neurological conditions. These early features can contribute to delays in diagnosis and referral, limiting timely access to specialist care, multidisciplinary support, and emerging therapies. The session will examine early signs across motor, bulbar, respiratory, and cognitive domains, with a focus on improving clinical recognition and differentiation from common mimics. Through a practical, case-based approach, participants will gain insights into identifying key red flags, navigating differential diagnosis, and initiating appropriate first-line investigations and referrals. Disclaimer: Informed consent was obtained from all the patients for the educational medical use of this content.