Management of Advanced Differentiated Thyroid Cancer: Clinical Decision-Making in Radioiodine-Refractory Disease

This accredited educational webinar addresses the clinical management of advanced differentiated thyroid cancer, with a particular focus on decision-making in patients with radioiodine-refractory disease. The session begins with a review of epidemiology and classification, followed by a practical discussion of diagnostic challenges and the patient journey from initial diagnosis to key therapeutic decision points. The program will explore the definition and clinical identification of radioiodine-refractory disease, emphasizing the criteria that guide the transition from observation to systemic treatment. The speakers will review pivotal clinical trials evaluating systemic treatment options, including a comparative overview of efficacy outcomes and their relevance in clinical practice. In addition, the session will analyze treatment efficacy in specific populations, as well as safety profiles and the practical management of adverse events associated with multikinase inhibitors. Strategies for optimal dosing and the importance of treatment individualization will also be addressed. The webinar will conclude with an interactive discussion and a Q&A session.